La enigmática señalización del ácido lisofosfatídico durante el desarrollo de las extremidades, la artritis reumatoide y la osteoartritis
Palabras clave:
Ácido lisofosfatídico, receptores acoplados a proteínas G, desarrollo de la extremidad, osteoartritis,, artritis reumatoideResumen
El ácido lisofosfatídico (LPA, del inglés lysophosphatidic acid) es un lípido bioactivo que tiene la
capacidad de unirse a receptores acoplados a las proteínas G y mediar a través de ellos distintas
respuestas celulares tales como: proliferación, migración, apoptosis y diferenciación celular.
En recientes años este lípido se ha visto involucrado en patologías como artritis reumatoide y
osteoartritis; sin embargo, evidencias sugieren que también puede jugar un papel importante
durante el desarrollo de las extremidades, así como de las articulaciones. Esta breve revisión
aborda un panorama general de los procesos en los que se ha visto involucrado el LPA tanto
en las patologías mencionadas y su posible papel en el desarrollo de la extremidad.
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