The enigmatic signaling of lysophosphatidic acid during limb development, rheumatoid arthritis, and osteoarthritis
Keywords:
Lisophosphatidic acid, G-protein coupled receptors, limb development, osteoarthritis, rheumatoid arthritisAbstract
Lisophosphatidic acid (LPA) is a bioactive lipid that binds to G-protein coupled receptors and
induces a variety of cell responses, including proliferation, differentiation, migration and apop-
tosis. Over the last few years, the behaviour of this lipid has been associated to rheumatoid
arthritis and osteoarthritis. However, some evidence suggests that LPA can play an important
role during limb and joint development. Present review describes the processes in which LPA
has been related to the above mentioned pathology and its possible roles on limb development.
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