Epilepsy as a disability problem
Keywords:
Epilepsy, disability, cognitionAbstract
Epilepsy is one of the most frequent neurological disorders, affecting some 50 million people
worldwide, of which 60% are undiagnosed or untreated despite the high effectiveness of the
pharmacological regimen. The disease is characterized by an abnormal synchronizati on and
increased neuronal electrical activity, and its etiology is variable. It presents with some level of
impairment in cerebral higher functions such as memory, attention, learning, behavior, etcetera,
resulting in a major cause of disability. Although there is progress in its study from the point
of view of molecular genetics, neurophysiology, imaging and psychopharmacology, epilepsy
continues to rank as a serious public health problem. A factor associated with the prevalence
of the disease that influences its progression is the disabling of patients, that is often an obstacle
to their social integration. This paper addresses general aspects of epilepsy as a public health
and disability problem, to promote a better understanding of the disease both among health
professionals and patients themselves.
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References
Stefanescu RA, Shivakeshavan RG, Talathi SS.
Computational models of epilepsy. Seizure. 2012; 21:
–759.
Figueroa-Duarte AS. Estudio clínico, epidemiológico y
sociocultural de la epilepsia: Un enfoque crítico. Arch
Neurocien. 2010; 15: 139-151.
Burneo JG, Tellez-Zenteno J, Wiebe S. Understanding
the burden of epilepsy in Latin America: a systematic
review of its prevalence and incidence. Epilepsy Res.
; 66 (1-3): 63-74.
López-Hernández E, Solís H. Epilepsia del lóbulo
temporal y las neuronas hipocampales de las áreas
CA1 y CA3. Rev de la Fac de Med UNAM. 2012; 55
(5): 16-25.
Desai JD. Epilepsy and cognition. J Pediatr Neurosci.
; 3(1): 16-29.
Cabo de la Vega C, Villanueva-Hernández P, Prieto-
Martín A. Neuroquímica de la epilepsia, neurotrans-
misión inhibitoria y modelos experimentales: nuevas
perspectivas. Rev Neurol. 2006; 42 (3): 159-168.
Cockerell OC, Johnson AL, Sander JW, Hart YM,
Shorvon SD. Remission of epilepsy: results from the
National General Practice Study of Epilepsy. Lancet.
; 346: 140-144.
López-Meraz ML, Rocha L, Miquel M, Hernández ME,
Toledo CR, Coria-Ávila GA et al. Conceptos básicos
de la epilepsia. Rev Med UV. 2009; 9 (2): 31-37.
Rubio-Donnadieu F. Aspectos generales y clasifi ca-
ción de la epilepsia. En: Feria Velasco A, Martínez
de Muñoz D, Rubio Donnadieu F. Epilepsia. México:
Cognos Editores; 1997. pp. 1-24.
Aronica EM, Gortler JA, Paupard MC, Grooms SY,
Bennett MV, Zukin RS. Status epilepticus-induced alte-
rations in metabotropic glutamate receptor expression in
young and adult rats. J Neurosci. 1997; 17: 8588–8595.
Fisher RS, Frost JJ. Epilepsy. J Nucl Med. 1991; 32:
-59.
Bell GS, Sander JW. The epidemiology of epilepsy:
the size of the problem. Seizure. 2001; 10: 306-316.
Engel J. Report of the ILAE classifi cation core group.
Epilepsia. 2006; 47: 1558-1568.
Meldrum B. Excitotoxicity and epileptic brain damage.
Epilepsy Res. 1991; 10: 55-61.
Takeda K, Nakata K, Takahashi S, Chikuma T, Kato
T. Effect of pentylenetetrazol treatment on cholecys-
tokinin mRNA and peptide levels in rat hippocampus
and cortex. Brain Res. 1998; 779: 320-323.
Mikati MA, Abi-Habib RJ, Sabban ME, Dbaibo GS,
Kurdi RM, Kobeissi M et al. Hippocampal program-
med cell death after status epilepticus: evidence for
NMDA-receptor and ceramide-mediated mechanisms.
Epilepsia. 2003; 44: 282-291.
García GME, García MI, Matías GI. Experimental
models in epilepsy. Neurología. 2010; 25 (3): 181-188.
Engel J. A proposed diagnostic scheme for people
with epileptic seizures and epilepsy: report of the ILAE
task force on classifi cation and terminology. Epilepsia.
; 42: 796–803.
Fisher RS, van Emde BW, Blume W, Elger C, Gen-
ton P, Lee P et al. Epileptic seizures and epilepsy:
definitions proposed by the International League
Against Epilepsy (ILAE) and the International Bureau
for Epilepsy (IBE). Epilepsia. 2005; 46: 470-472.
Kanner AM. Depression in epilepsy: a complex relation
with unexpected consequences. Curr Opin Neurol.
; 21: 190-194.
Carrizosa MJ. Efectos cognitivos de los medicamentos
antiepilépticos. Iatreia. 2009; 22 (4): 350-358.
Herrera-Peco I, Fernández-Millares V, Pastor J,
Hernando-Requejo V, Sola RG, Alonso-Cerezo C.
Factores genéticos asociados a la epilepsia del lóbulo
temporal. Rev Neurol. 2009; 49: 541-546.
Ávila AJM. Comorbilidad del trastorno compulsivo en
pacientes con epilepsia. Arch Neurocien. 2004; 9: 94-99.
World Health Organization. Epilepsy: epidemiology,
aetiology and prognosis. WHO factsheet. 2001.
Asconapé JJ. Epilepsias. En: Micheli F, Fernández PM.
Neurología. México: Panamericana; 2010. pp 87-109.
Lee TMC, Chan JKP. Factores que afectan el esta-
do cognitivo de personas que sufren epilepsia. Rev
Neurol. 2002; 34 (9): 861-865.
Commission on Classifi cation and Terminology of
the Internacional League Against Epilepsy, ILAE.
Proposal for revised classifi cation of epilepsies and
epilectic syndromes. Epilepsia. 1989; 30: 389-399.
Jefferys JGR. Advances in understanding basic me-
chanisms of epilepsy and seizures. Seizure. 2010;
: 638-646.
Reséndiz-Aparicio JC, Aguirre-García. Epilepsia in-
fantil, diez puntos básicos para el psiquiatra. Salud
Mental. 2011; 34 (5): 451-457.
Engel JJ. Concepts of epilepsy. Epilepsia. 1995; 36
(1): 23-29.
Van Rijckevorsel. Cognitive problems related to epi-
lepsy syndromes, especially malignant epilepsies.
Seizure. 2006; 15: 227-234.
Linehan C, Tellez-Zenteno JF, Burneo JG, Berg AT.
Future direcions for epidemiology in epilepsy. Epilep-
sy Behav. 2011; 22: 112-117.
Banerjee PN, Filippi D, Hauser WA. The descriptive
epidemiology of epilepsy-a review. Epilepsy Res.
; 85 (1): 31-45.
Berg A, Berkovic S, Brodie M, Buchhalter J, Cross
J, van Emde Boas W et al. Revised terminology and
concepts for organization of seizures and epilepsies:
report of the ILAE Commission on Classifi cation and
Terminology, 2005-2009. Epilepsia. 2010; 51: 676-685.
Carpio A, Pesantes J. Neurocisticercosis y epilepsia.
En: Campos M, Kanner A. Epilepsias. Diagnóstico y
Tratamiento. Santiago: Mediterráneo; 2004.
World Health Organization–International League
against Epilepsy–International Bureau for Epilepsy.
Atlas: Epilepsy Care in the World 2005. Ginebra,
Suiza: WHO; 2005. Disponible en: http://www.who.
int/mental_health/neurology/Epilepsy_atlas_r1.pdf
Organización Mundial de la Salud. Trastornos neuroló-
gicos: desafíos para la salud pública. Ginebra, Suiza:
OMS; 2006. Disponible en: http://new.paho.org/hq/
dmdocuments/2008/Trastornos_Neurologicos.pdf
Organización Panamericana de la Salud/Organización
Mundial de la Salud–Liga Internacional Contra la Epi-
lepsia–Buró Internacional para la Epilepsia. Informe
sobre la Epilepsia en Latinoamérica. Panamá: 2008.
Disponible en: http://www.infocom-ca.org.pa/fi les/
Informe%20epilepsia.pdf
Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW,
Newton CR. Estimation of the burden of active and
life-time epilepsy: a meta-analytic approach. Epilep-
sia. 2010; 51: 883–890.
Uribe CS, Acevedo SE, Vallejo D. Las epilepsias,
status epileptic. En: Uribe US, Arana CA, Lorenzana.
Neurología. 7a ed. Medellín, Colombia: Corporación
para Investigaciones Biológicas; 2010.
Hauser WA, Annegers JF, Kurland LT. Incidence
of epilepsy and unprovoked seizures in Rochester,
Minnesota: 1935-1984. Epilepsia. 1993; 34: 435-468.
Lhatoo SD, Sander WAS. The Epidemiology of Epilepsy
and Learning Disability. Epilepsia. 2001; 42 (Suppl 1): 6-9.
Walczak TS, Leppik IE, D’Amelio M, Rarick J, So E,
Ahman P et al. Incidence and risk factors in sudden
unexpected death in epilepsy: a prospective cohort
study. Neurology. 2001; 56: 519-525.
Nashef L, Hindocha N, Makoff A. Risk factors for
sudden death in epilepsy (SUDEP). Epilepsia. 2007;
: 859–871.
Christensen J, Vestergaard M, Mortensen PB, Sidenius
P, Agerbo E. Epilepsy and risk of suicide: a population-
based control study. Lancet Neurol. 2007; 6: 693-698.
Jiménez I, Mora O, Uribe S, Isaza R, Sánchez JL,
Muñoz A et al. Factores de riesgo en la epilepsia.
Estudio epidemiológico de casos y controles. Acta
Medica Colombiana. 1991; 16 (1): 5-17.
Li X, Sundquist J, Sundquist K. Socioeconomic and
occupational risk factors for epilepsy: a nationwide
epidemiological study in Sweden. Seizure. 2008; 17
(3): 254-260.
World Health Organization. World report on disability
Malta: WHO; 2011.
Etchepareborda MC. Epilepsia y aprendizaje: enfoque
neuropsicológico. Rev Neurol. 1999; 28 (2): 142- 149.
Suárez-Escudero JC. Evaluación, seguimiento y
rehabilitación controlada de la función motora en
pacientes con cirugía de epilepsia fármaco resistente.
Acta Neurol Colomb. 2012; 28 (2): 85-93.
García Peñas JJ. Repercusión neurocognitiva de las
descargas epileptiformes interictales en el niño. Rev
Neurol. 2011; 52 (1): S43-S52.
Taylor DC, Neville BG, Cross JH. Autistic spectrum
disorders in childhood epilepsy surgery candidates.
Eur Child Adolesc Psychiatry. 1999; 8: 189-192.
Dunn DW, Austin JK, Harezlak J et al. ADHD and epilepsy
in childhood. Dev Med Child Neurol. 2003; 45: 50-54.
Neville BG, Boyd SG. Selective epileptic gait disorder.
J Neurol Neurosurg Psychiatry. 1995; 58: 371-373.
Maestú F, Martín P, Solá RG, Ortiz T. Neuropsicología
y deterioro cognitivo en la epilepsia. Rev Neurol. 1999;
(8): 793-798.
Malagón-Valdez J. Efectos cognitivos de los fármacos
antiepilépticos. Rev Neurol. 2003; 36: 288-292.
Perrine K, Kiolbasa T. Cognitive defi cits in epilepsy
and contribution to psychotherapy. Neurology. 1999;
(2): 39-48.
Schwartzkroin PA, Wyler AR. Mechanisms underlying
epileptic form burst discharge. Ann Neurol. 1979; 7:
-107.
Mendoza BC, Gómez AB. La psicosis en epilepsia.
Rev Colomb Psiquiatr. 2009; 38 (4): 739-760.
Hermann BP, Wyler AR, Somes G. Language function
following anterior temporal lobectomy. J Neurosurg.
; 74: 5606.
Fastenau PS, Shen J, Dunn D, Perkins S, Hermann B,
Austin J. Neuropsychological predictors of academic
underachievement in pediatric epilepsy: Moderating
roles of demographic, seizure and psychosocial va-
riables. Epilepsia. 2004; 45 (10) 1261-1272.
Herranz JL. Factores clínicos y sociales que modulan
el tratamiento de los niños con epilepsia. Bol Pediatr.
; 42: 230-240.
Sillanpaa M, Jalava M, Kaleva O et al. Long-term prog-
nosis of seizures with onset in childhood. N Engl J Med.
; 338: 1715-1722.
Tavera SLM, Álvarez AE, Izquierdo BA, Cabrera SC,
Vásquez P. Caracterización de los problemas de apren-
dizaje en niños y adolescentes con epilepsia primaria
generalizada. Medicina. 2011; 33 (4): 227-248.
Beghi M, Cornaggia O, Frigeni B, Beghi E. Learning
disorders in epilepsy. Epilepsia. 2006; 47 (2): 14-18.
Besag F. Cognitive and behavioral outcomes of epilep-
tic syndromes: Implications for education and clinical
practice. Epilepsia. 2006; 47: 119-125.
Henkin Y. Cognitive function in idiopathic generalized
epilepsy in childhood. Develop Med Child Neurol 2005;
: 126-132.
Campos-Castelló J. Neuropsicología de la epilepsia:
¿qué factores están implicados? Rev Neurol. 2006; 43
(1): 59-70.
Kanner AM, Balabanov A. Depression and epilepsy: how
closely related are they? Neurology. 2002; 58: 27-39.
Motamedi G, Meador K. Epilepsy and cognition. Epilepsy
Behav. 2003; 4 (2): 25-38.
Camfi eld C, Camfi eld P, Smith B, Gordon K, Dooley
J. Biologic factors as predictors of social outcome of
epilepsy in intellectually normal children: a population-
based study. J Pediatr. 1993; 122: 869-873.
Shackleton DP, Kasteleijn-Nolst DGA, de Craen AJM,
Vandenbroucke JP, Westendorp RGJ. Living with epi-
lepsy: Long-term prognosis and psychosocial outcomes.
Neurology. 2003; 61: 64–70.
Gaitatzis A, Carroll K, Majeed A, Sander JW. The epi-
demiology of the comorbidity of epilepsy in the general
population. Epilepsia. 2004; 45: 1613-1622.
Strine T, Kobau R, Chapman D, Thurman D, Price P, Ba-
lluz L. Psychological distress, comorbidities, and health
behaviors among U.S. adults with seizures: results from
the 2002 National Health Interview Survey. Epilepsia.
; 46: 1133-1139.
Tellez-Zenteno JF, Patten SB, Jette N, Williams J, Wiebe
S. Phychiatric comorbidity in epilepsy: A population-
based analysis. Epilepsia. 2007; 48: 2336-2344.
Battaglia D, Rando T, Deodato F, Bruccini G, Baglio G,
Frisone MF et al. Epileptic disorders with onset in the
fi rst year of life: neurological and cognitive outcome.
Eur J Paediat Neurol. 1999; 3: 95-103.
Dodrill CB. Neuropsychological aspects of epilepsy.
Psychiatr Clin North Am. 1992; 15: 383-394.
Aldenkamp AP, Arends J. Effects of epileptiform EEG
discharges on cognitive function: Is the concept of
«transient cognitive impairment» still valid? Epilepsy
Behav. 2004; 5: 25-34.
Ortinski P, Meador KJ. Cognitive side effects of epileptic
drugs. Epilepsy Behav. 2004; 5 (1): 60-65.
Aguilar FL, Morgade FRM, Rodríguez VRF, Álvarez AA.
Deterioro cognitivo en la epilepsia. Rev Mex Neuroci.
; 7 (3): 218-224.
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