The basal ganglia: striatal dopaminergic involvement
Keywords:
Dopamine, neostriatum, D1 receptor, D2 receptor, dopamine release, basal gangliaAbstract
Basal ganglia are associated to motor and non-motor functions. The neostriatum nucleus is
involved into basal ganglia, and its function is critically dopamine-regulated by activation of
post-synaptic D1
and D2
receptors, which are present in mid-size spinous neurons, in the middle
of direct striato-nigral and indirect striato-palidal pathways, respectively. Striatal dopamine
release after application of dopaminergic agonists and antagonists is explained through the
negative backfeeding system that involves those pre- and post-synaptic receptors. The study
of dopaminergic striatal system may enhance the understanding of the basal ganglia function
as well as their disfunction. The present paper intends to explain the striatal dopaminergic
participation in basal ganglia and their motor function.
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