Comparison of the Foveal Avascular Zone Between Patients With High Myopia and Emmetropic Subjects Using OCT Angiography
Keywords:
High myopia, foveal avascular zone, OCT angiography, retinal microvasculature, non-invasive imaging, macular perfusionAbstract
Background: High myopia is a growing global concern, often leading to irreversible macular damage. The foveal avascular zone (FAZ), a marker of retinal microcirculation, may be altered in highly myopic eyes even before clinical signs emerge.
Purpose: To compare FAZ area and morphology in patients with high myopia versus emmetropic subjects using optical coherence tomography angiography (OCT-A).
Methods: We conducted a retrospective, cross-sectional study including 62 eyes (31 per group). Subjects aged 18–65 with BCVA ≥ 20/25 and no retinal pathology were included. FAZ area was manually measured in superficial and deep capillary plexuses from OCT-A images obtained with Optovue®. Statistical analysis included Shapiro-Wilk and Mann-Whitney U tests.
Results: We expect to find a significantly larger and more irregular FAZ in the high myopia group, suggesting early microvascular compromise.
Conclusion: FAZ metrics may serve as non-invasive biomarkers of subclinical retinal alteration in high myopia. OCT-A imaging could be integrated into routine screening for earlier detection of risk.
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Copyright (c) 2025 Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra under a Creative Commons Attribution 4.0 International (CC BY 4.0) license which allows to reproduce and modify the content if appropiate recognition to the original source is given.
