Thermal ablation: an alternative to bone cancer

Authors

  • Citlalli J. Trujillo-Romero División de Investigación en Ingeniería Médica, Instituto Nacional de Rehabilitación, “Luis Guillermo Ibarra Ibarra".
  • Genaro Rico-Martínez Departamento de Tumores Óseos, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”.
  • Josefina Gutiérrez-Martínez División de Investigación en Ingeniería Médica, Instituto Nacional de Rehabilitación, “Luis Guillermo Ibarra Ibarra".

Keywords:

bone tumor, thermotherapy, thermal ablation, bone metastasis, modeling

Abstract

The present work is a bibliographic review about the most common therapies to treat bone tumors (surgery, radiotherapy and chemotherapy). An analysis of the most important advantages, disadvantage, side effects and costs of each therapy was done. On the other hand, an exhausted research of the new treatment techniques called thermotherapies (ablation specifically) is presented. The main goal is to define, taking into account its characteristics, if thermal ablation can be considered as a new alternative to treat bone tumor, and even if it can be a better option than the conventional therapies. Some clinical studies and modelling analysis have shown good results in the treatment of bone tumors with thermal ablation (tumor temperatures above 70°C). According to some studies, thermal ablation is very useful in bone metastasis, due to the pain reduction in the patients. Finally, a simple model of a MW antenna for thermal ablation is presented in order to show its interaction with bone tissue.

References

Vernon CC, Hand JW, Field SB, Machin D, Whaley

JB. Radiotherapy with or without hyperthermia in the

treatment of superficial localized breast cancer:

results from five randomized controlled trials. Int J

Radiat Oncol BiolPhys. 1996;35(4):731-744.

Linthorst M, Drizdal T, Joosten H, van Rhoon GC, van

der Zee J. Procedure for creating a three-dimensional

(3D) model for superficial hyperthermia treatment

planning. Strahlenther Onkol. 2011;187(12):835-841.

Scott SJ, Prakash P, Salgaonkar V, et al. Approaches

for modelling interstitial ultasound ablation of tumours

within or adjacent to bone : Theoretical and

experimental evaluations. Int J Hyperthermia. 2013

;6736(7):629-642.

Ruiz Santiago M, Castellano García M, Martınez

Montes JL, Trista Fernández JM. Treatment of bone

tumours by radiofrequency thermal ablation. Curr Rev

Musculoskelet Med. 2009;2:43-50.

American Cancer Society. Treating Bone Cancer.

https://www.cancer.org/cancer/bone-

cancer/treating.html. Published 2017.

Habash RWY, Bansal R, Krewski D, Alhafid HT.

Thermal therapy, part 2: hyperthermia techniques.

Crit Rev Biomed Eng. 2006;34(6):491-542.

Hernández AV, Enrique J, Quero C, Salas LL,

Marchal C. Hipertermia electromagnética, una

alternativa para el tratamiento del cáncer:

antecedentes, aspectos físicos y biológicos. 2001;

XXII:78-88.

Habash RWY, Bansal R, Krewski D, Ha T. Thermal

Therapy , Part III : Ablation. Crit Rev Biomed Eng.

;35:37-121.

Simon CJ, Dupuy DE, William W. Microwave Ablation:

Principles and Applications. Radiographics. 2005;

:69-84.

Martínez GR, Cedillo ED, Villaseñor EE, Guzmán

RG, Pineda NF. Los dilemas en tumores óseos. Acta

Ortopédica Mex. 2007;21(6):349-353.

Olszta MJ, Cheng X, Soo S, et al. Bone structure and

formation : A new perspective. Mater Sci Eng R.

:1-40. doi:10.1016/j.mser.2007.05.001.

Artner J. Atlas of Human Skeletal Anatomy.; 2002.

Wojnar R. Bone and Cartilage – Its Structure and

Physical Properties. (Ochsner A, Ahmed W, eds.).;

American Cancer Society. Guía Detallada del Cáncer

de Hueso. http://www.cancer.org/espanol/cancer

/cancerdehuesos/index. Published 2015. Accessed

October 26, 2016.

aecc contra el Cáncer. Tratamiento quirúrgico.

https://www.aecc.es/SobreElCancer/CancerPorLocali

zacion/cancerdeovario/Paginas/tratamientoquirurgico.

aspx. Published 2017.

Han W, Yu KN. Response of Cells to Ionizing

Radiation. In: S.C.Tjong, ed. Advances in Biomedical

Sciences and Engineering. Bentham Science;

:320.

Koizumi M, Inoue T, Yamazaki H, et al. Perioperative

fractionated high-dose rate brachytherapy for

malignant bone and soft tissue tumors. Int J Radiat

Oncol Biol Phys. 1999;43(5):989-993.

Gok B, McGirt MJ, Sciubba DM, et al. Adjuvant

treatment with locally delivered oncogel delays the

onset of paresis after surgical resection of

experimental spinal column metastasis. Neuro-

surgery. 2009;65(1):193-199.

Spine N, Scale KP, Evaluation R, et al. A preliminary

comparative clinical study of vertebroplasty with

multineedle od single-needle interstitial implantation

of 125I seeds in the treatment of osteolytic metastatic

vertebral tumors. J Neurosurg Spine. 2014;20(April):

-435.

Feng S, Wang L, Xiao Z, et al. 125I Seed Implant

Brachytherapy for Painful Bone Metastases After

Failure of External Beam Radiation Therapy.

Medicine (Baltimore). 2015;94(31):e1253.

Humm JL, Sartor O, Parker C, Bruland OS, Macklis

R. Radium-223 in the Treatment of Osteoblastic

Metastases: A Critical Clinical Review. Int J Radiat

Oncol. 2015;91(5):898-906.

Rosenberg I. Radiation Oncology Physics: A

Handbook for Teachers and Students. Int At Energy

Agency. 2005;98(5):1020.

Ballester, F. Udías J. Física Nuclear y Medicina. Rev

Española Física. 2008;22(1):29-36.

Antonio M, Bracamontes M, José J. Metodología

para la selección de una máquina de megavoltaje

para el servicio de radioterapia en un hospital del

sector salud. Rev Ing Eléctrica, Eléctronica y Comput.

;4(1):25-29.

American Cancer Society. Chemotherapy Drugs :

How They Work. Am Cancer Soc. 2015:17.

Kashima TG, Gamage NG, Dirksen U, Gibbons CL,

Ostlere SJ, Athanasou N a. Localized Ewing sarcoma

of the tibia. Clin Sarcoma Res. 2013;3(1):2.

van der Zee J, González González D, van Rhoon

GC, van Dijk JD, van Putten WL, Hart a a.

Comparison of radiotherapy alone with radiotherapy

plus hyperthermia in locally advanced pelvic tumours:

a prospective, randomised, multicentre trial. Dutch

Deep Hyperthermia Group. Lancet. 2000;355

(9210):1119-1125.

Gautherie DM, ed. Whole Body Hyperthermia:

Biological and Clinical Aspects. Springer Berlin

Heidelberg; 1992..

Szasz A, Iluri N, Szasz O. Local Hyperthermia in

Oncology – To Choose or not to Choose ? In:

Hyperthermia. ; 2013:1-82.

van der Zee J. Heating the patient: a promising

approach? Ann Oncol. 2002;13(8):1173-1184.

Beck M, Ghadjar P, Weihrauch M, et al. Regional

hyperthermia of the abdomen, a pilot study towards

the treatment of peritoneal carcinomatosis. Radiat

Oncol. 2015;10(1):157.

Hasgall P, Neufeld E, Gosselin M, Klingenbock A,

Kuster N. IT’IS database for thermal and electro-

magnetic parameters of biological tissues. http://www.

itis.ethz.ch/itis-for-health/tissue-properties/overview/.

Published 2012.

Van Der Zee J, De Bruijne M, Mens JWM, et al.

Reirradiation combined with hyperthermia in breast

cancer recurrences: overview of experience in

Erasmus MC. Int J Hyperth. 2010;26(7):638-648.

Van Der Zee J, Rietveld PJ. M, Broekmeyer-Reurink

MP, Wielheesen D. HM, van Rhoon GC.

Hyperthermia in recurrent breast cancer: from

experimental oncology to standard practice. Exp

Oncol. 2002;2002(24):45-50.

Dupuy DE, Goldberg SN. Image-guided radiofreque-

ncy tumor ablation: challenges and opportunities--part

II. J Vasc Interv Radiol. 2001;12(10):1135-1148.

Gebauer B, Tunn P. Thermal Ablation in Bone

Tumors. In: Minimally Invasive Tumor Therapies. Vol

; 2006:135-146.

Knavel E, Brace C. Tumor Ablation: Common

Modalities and Generak Practices. Tech Vasc Interv

Radiol.2013;16(4):192-200.

Nazario J, Hernandez J, Tam AL. Thermal Ablation

of Painful Bone Metastases. Tech Vasc Interv Radiol.

;14(3):150-159.

Albisinni U, Bazzocchi A, Bettelli G, et al. Treatment

of osteoid osteoma of the elbow by radiofrequency

thermal ablation. J Shoulder Elb Surg. 2014;23(1):e1-

e7.

Lanza E, Thouvenin Y, Viala P, et al. Osteoid

Osteoma Treated by Percutaneous Thermal Ablation:

When Do We Fail? A Systematic Review and

Guidelines for Future Reporting. Cardiovasc Intervent

Radiol. 2013:1-10.

Pimolsanti R, Wongkajornsilpa A, Chotiyarnwong P,

Asavamongkolku A. Effects of thermoablation with or

without caffeine on giant cell tumour of bone.

;23(1):95-99.

Ruiz Santiago F, Del Mar Castellano García M,

Guzmán Álvarez L, Martínez Montes JL, Ruiz García

M, Tristán Fernández JM. Percutaneous treatment of

bone tumors by radiofrequency thermal ablation. Eur

J Radiol. 2011;77(1):156-163.

Nicholas Kurup A, Callstrom MR. Ablation of

musculoskeletal metastases: Pain palliation, fracture

risk reduction, and oligometastatic disease. Tech

Vasc Interv Radiol. 2013;16(4):253-261.

Dupuy DE, Goldberg SN. Image-guided

Radiofrequency Tumor Ablation : Challenges and

Opportunities — Part II. J Vasc Interv Radiol. 2001;

(10):1135-1148.

Liu Z, Ahmed M, Sabir A, Humphries S, Goldberg

SN. Computer modeling of the effect of perfusion on

heating patterns in radiofrequency tumor ablation. Int

J Hyperthermia. 2007;23(February):49-58.

Filippiadis DK, Tutton S, Kelekis A. Percutaneous

bone lesion ablation. Radiol Medica. 2014;

(7):462-469.

Deschamps F, Farouil G, Ternes N, et al. Thermal

ablation techniques: A curative treatment of bone

metastases in selected patients? Eur Radiol.

;24(8):1971-1980. -1.

Santiago FR, Del Mar Castellano García M, Montes

JLM, García MR, Fernández JMT. Treatment of bone

tumours by radiofrequency thermal ablation. Curr Rev

Musculoskelet Med. 2009;2(1):43-50.

Hoffmann RT, Jakobs TF, Kubisch CH, et al.

Radiofrequency ablation in the treatment of osteoid

osteoma-5-year experience. Eur J Radiol.

;73(2):374-379.

Carrafiello G, Laganà D, Mangini M, et al. Microwave

tumors ablation: Principles, clinical applications and

review of preliminary experiences. Int J Surg.

;6(SUPPL. 1):65-69..

Scott SJ, Salgaonkar V, Prakash P, Burdette EC,

Diederich CJ. Interstitial ultrasound ablation of

vertebral and paraspinal tumours: Parametric and

patient-specific simulations. Int J Hyperth. 2014;

(4):228-244.

Brace CL. Radiofrequency and Microwave Ablation

of the Liver, Lung, Kidney, and Bone: What Are the

Differences? Curr Probl Diagn Radiol. 2009

;38(3):135-143.

Fan Q-Y, Ma B-A, Zhou Y, Zhang M-H, Hao X-B.

Bone Tumors of the Extremities or Pelvis Treated by

Microwave-Induced Hyperthermia. Clin Orthop Relat

Res. 203AD;406(1):165-175.

Pusceddu C, Sotgia B, Fele RM, Melis L. Treatment

of Bone Metastases with Microwave Thermal

Ablation. J Vasc Interv Radiol. 24(2):229-233.

Metastasis B, Napoli A, Anzidei M, et al. MR Imaging

– guided Focused Ultrasound for Treatment of.

:1555-1569.

Al-Bataineh O, Jenne J, Huber P. Clinical and future

applications of high intensity focused ultrasound in

cancer. Cancer Treat Rev. 2012;38(5):346-353.

Chen W, Zhu H, Zhang L, et al. Primary bone

malignancy: effective treatment with high-intensity

focused ultrasound ablation. Radiology.

;255(3):967-978.

Maloney E, Hwang JH. Emerging HIFU applications

in cancer therapy. Int J Hyperth. 2014;(August):1-8.

Gutiérrez-Martínez J, Rico-Martínez G. Sistema de

hipertermia hidrica controlada con mapeo para

oncología ósea. Rev Mex Ing Biomédica. 2008;

XXIX(1):7-14.

Gastélum R, Rico M, Vega I, et al. Efecto biológico

de la hipertermia hídrica controlada sobre hueso sano

de conejos. Acta Ortopédica Mex. 2014;28(5):297-

Franckena M. Hyperthermia for the Treatment of

Locally Advanced Cervix Cancer.; 2010.

http://repub.eur.nl/res/pub/20549/.

Okhai T a, Smith CJ. Principles and Application of

RF System for Hyperthermia Therapy. In:

Hyperthermia. ; 2013:171-184.

National Institute of Integrative Medicine. Regional

Hyperthermia Clinical Trial. http://www.niim.com.

au/clinic/services/hyperthermia/hyperthermia-faq#q8.

Published 2015.

Asociación Mexicana de Lucha Contra el Cáncer .

Osteosarcoma: el cáncer de hueso más común de la

edad pediátrica. Rayuela Rev Iberoaméricama Sobre

Niñez y Juv en Lucha por sus Derechos.:215-222.

Martinez Tello F, Manjón Luengo P, Montes Moreno

S. Variantes de condrosarcoma. Rev española Patol.

;39(2):69-79.

Melo IG, Martínez VC. Tumores Oseos Condroides:

Condromas Versus Condrosarcomas Conven-

cionales. Rev Chil Radiol. 2005;11(1):170-178.

Bernstein M, Kovar H, Paulussen M, Randall

RL, Schuck A, Teot LA. Ewing ’ s Sarcoma Family of

Tumors : Current Management. Oncologist.

;11(C):503-519.

Parikh M, Samujh R, Kanojia RP. Peripheral

Primitive Neuroectodermal Tumor of the Chest Wall in

Childhood : Clinico-Pathological Significance ,

Management and Literature Review. Chang Gung

Med J. 2011;34(2):213-217.

Salvador J, Olalde U, Guillermo H, et al. Sarcoma de

Ewing extraóseo. Bol Med Hosp Infant Mex.

;70(6):477-481.

Fletcher CDM, Unni KK. World Health Organization

Classification of Tumours Pathology and Genetics of

Tumours of Soft Tissue and Bone.; 2002.

Romeo S, Bovée JVMG, Kroon HM, et al. Malignant

fibrous histiocytoma and fibrosarcoma of bone: A re-

assessment in the light of currently employed

morphological, immunohistochemical and molecular

approaches. Eur J Pathol. 2012;461(5):561-570.

Rosa-pérez LJH. Tumores malignos de los huesos.

In: Cirugía: II Cirugía Ortopédica Y Traumatología.

Universidad Nacional Mayor de San Marcos (Lima).

Facultad de Medicina. Escuela Académico

Profesional de Medicina Humana. Departamento

Académico de Cirugía; 2000:305-318.

Mercado MV, Samith MA, Ghiringhelli MA, et al.

Fibrosarcoma: Caso clínico. Rev Otorrinolaringol,.

:241-249.

Chakarun CJ, Forrester DM, Gottsegen CJ, Patel

DB, White E a, Matcuk GR. Giant cell tumor of bone:

review, mimics, and new developments in treatment.

Radiographics. 2013;33(1):197-211.

Óleas Poveda J, Alvarado Chávez T, Abad Ramirez

C. Tumor de células gigantes malignizado.

Presentación de un caso. MedPre, Rev Interuniv e

Interhospitalaria del Ecuador. 2011;1(1):49-53.

Marxen J, Uribe T. Tumor de células gigantes de

hueso: trasformación maligna secundaria sin

radioterapia. Rev Médico Cient. 2001;14(2):28-35.

Bryson DJ, Wicks L, Ashford RU. The investigation

and management of suspected malignant

pathological fractures: A review for the general

orthopaedic surgeon. Injury. 2015:1-9.

American Cancer Society. Metástasis En Los Hue-

sos. ; 2014.

Therapy R, Cdks B. The Science Behind Radiation

Therapy. Am Cancer Soc. 2014:15.

Icrp. Annals of the ICRP 60.; 1990.

Wodaje T. Long Term Effects of Radiation-Induced

Osteonecrosis of the Pelvis Caused Complete Failure

of Total Hip Arthroplasty. Surg Sci. 2012;3(7):373-

Mitsimponas KT, Moebius P, Amann K, et al. Osteo-

radio-necrosis (ORN) and bisphosphonate-related

osteonecrosis of the jaws (BRONJ): The

histopathological differences under the clinical

similarities. Int J Clin Exp Pathol. 2014;7(2):496-508.

Oh D, Huh SJ. Insufficiency fracture after radiation

therapy. Radiat Oncol J. 2014;32(4):213-220.

Nicholls F, Janic K, Filomeno P, Willett T, Grynpas

M, Ferguson P. Effects of radiation and surgery on

healing of femoral fractures in a rat model. J Orthop

Res. 2013;31(8):1323-1331.

Bluemke D a, Fishman EK, Scott WW. Skeletal

complications of radiation therapy. Radiographics.

;14(1):111-121.

Agency for Healthcare Research and Quality.

Statistical Brief #125. Healthcare Cost and Utilization

Project (HCUP). www.hcup-us.ahrq.gov/reports

/statbriefs/sb125.jsp. Published 2012.

Ramirez-Agudelo V. Estudio de Factibilidad Para La

Unidad de Radioterapia Del Centro Oncológico de

Antioquia S.A.; 2014.

Hess G, Barlev A, Chung K, Hill JW, Fonseca E.

Cost of palliative radiation to the bone for patients

with bone metastases secondary to breast or prostate

cancer. Radiat Oncol. 2012;7(1):168.

Nickman NA, Ye X, Gaffney DK, et al. radiotherapy (

EBRT ) use for bone. J Community Support Oncol.

;13(3):95-103.

Health A. Total Cost of Cancer Care by Site of

Service : Physician Office vs Outpatient Hospital.

;(March).

Published

2024-07-25

How to Cite

1.
Trujillo-Romero CJ, Rico-Martínez G, Gutiérrez-Martínez J. Thermal ablation: an alternative to bone cancer. Invest. Discapacidad [Internet]. 2024 Jul. 25 [cited 2024 Dec. 22];7(1):35-46. Available from: https://dsm.inr.gob.mx/indiscap/index.php/INDISCAP/article/view/153

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Evidence synthesis and meta-research

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