Animal models of pain in the study of fibromyalgia
DOI:
https://doi.org/10.35366/113832Keywords:
fibromyalgia, animal models, pain, stress, anxiety, depressionAbstract
Fibromyalgia (FM) is a chronic and diffuse type of musculoskeletal pain of non-articular origin. It is characterized by the combination of several symptoms, mainly by the subjective presence of generalized pain, fatigue, morning stiffness and sleep disturbance. The etiology of the disease is multifactorial and nowadays continues to be the subject of study by many research groups. On the other hand, due the complexity of the disease, the implementation of animal models has been proposed, however, choosing the appropriate animal model that meets the characteristics of the symptoms of the disease has generated discrepancies among researchers. For this reason, the objective of this review is to analyze the animal models of pain for the study of fibromyalgia. Search strategies were developed for each database consulted: PubMed, the Web of Science and Embase. The search strategy was carried out using the keywords «fibromyalgia, pain, animal models of pain, generalized pain, chronic pain, neuropathic pain». Pain models were analyzed. The models that are mainly based on pain, whether chronic or neuropathic, are the ones that possess more similarities to the pathology, however, it is not possible to evaluate the emotional component of it, and it is such an important part of the symptoms of fibromyalgia. The complexity of the symptomatology of the disease generates limitations in animal models of pain. The development of experimental designs with animal models of pain for the study of fibromyalgia must consider the limitations analyzed in this review.
References
Clauw D, Sarzi-Puttini P, Pellegrino G, Shoenfeld Y. Is fibromyalgia an autoimmune disorder? Autoimmun Rev. 2023; 25: 103424.
López M, Mingote J. Fibromialgia. Clínica y Salud. 2008; 19 (3): 343-358.
Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983; 16 (2): 109-110.
Olfert ED, Cross BM, McWilliam AA. Guide for the care and use of experimental animals. Can Council Anim Care. 1993; 1: 1-211.
Bravo L, Llorca-Torralba M, Suárez-Pereira I, Berrocoso E. Pain in neuropsychiatry: insights from animal models. Neurosci Biobehav Rev. 2020; 115: 96-115.
Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988; 33 (1): 87-107.
Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990; 43 (2): 205-218.
Kim SH, Chung JM. An experimental model for peripheral neuropathic produced by segmental spinal nerve ligation in the rat. Pain. 1992; 50: 355-363.
Le Bars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev. 2001; 53 (4): 597-652.
Beecher HK. The measurement of pain: prototype for the quantitative study of subjective responses. Pharmacol Rev. 1957; 9 (1): 59-209.
Lineberry CG. Laboratory animals in pain research, in methods in animal experimentation. Vol. 6. New York: Academic Press; 1981. pp. 237-311.
Borszcz GS, Johnson CP, Fahey KA. Comparison of motor reflex and vocalization thresholds following systemically administered morphine, fentanyl, and diazepam in the rat: assessment of sensory and performance variables. Pharmacol Biochem Behav. 1994; 49 (4): 827-834.
Eddy NB, Leimbach D. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther. 1953; 107 (3): 385-393.
Bannon AW, Malmberg AB. Models of nociception: hot-plate, tail-flick, and formalin tests in rodents. Curr Protoc Neurosci. 2007; Chapter 8: Unit 8.9.
Carter RB. Differentiating analgesic and non-analgesic drug activities on rat hot plate: effect of behavioral endpoint. Pain. 1991; 47: 211-220.
Plone MA, Emerich DF, Lindner MD. Individual differences in the hot-plate test and effects of habituation on sensitivity to morphine. Pain. 1996; 66: 265-270.
Knoll J, Kelemen K, Knoll B. Experimental studies on the higher nervous activity of animals. I. A method for the elaboration of a non-extinguishable conditioned reflex in the rat. Acta Physiol Hung. 1995; 8: 327-344.
Espejo EF, Mir D. Structure of the rat’s behaviour in the hot plate test. Behav Brain Res. 1993; 56 (2): 171-176.
Barrot M. Tests and models of nociception and pain in rodents. Neuroscience. 2012; 211: 39-50.
Hardy JD, Wolff HG, Goodell H. Studies on pain. A new method for measuring pain threshold: observation on spatial summation of pain. J Clin Invest. 1940; 19: 649-657.
D’Amour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther. 1941; 72: 74-79.
Smith DL, D’Amour MC, D’Amour FE. The analgesic properties of certain drugs and drug combinations. J Pharmacol Exp Ther. 1943; 77: 184-193.
Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cats. Pain. 1977; 4: 161-174.
Cortes‑Altamirano JL, Reyes‑Long S, Bonilla‑Jaime H, Clavijo‑Cornejo D, Vargas J, Bandala C et al. Acute administration of levetiracetam in tonic pain model modulates gene expression of 5HT1A and 5HT7 receptors in the thalamus of rats (Rattus norvergicus). Mol Bio Rep. 2020; 47 (5): 3389-3396.
Abbott FV, Franklin KB, Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain. 1995; 60: 91-102.
Abbott FV, Ocvirk R, Najafee R, Franklin KB. Improving the efficiency of the formalin test. Pain. 1999; 83: 561-569.
Tjolsen A, Hole K. The effect of morphine on core and skin temperature in rats. Neuroreport. 1992; 3: 512-514.
Garrido B, Bosch F, Garrido G, Hernández-Balmaseda I, Delgado-Hernández R, 2007. Modelos animales de dolor y electroacupuntura. Rev Soc Esp Dolor 2007;14(4): 296-306.
Radhakrishnan R, Bement MK, Skyba D, Sluka KA, Kehl LJ. Models of muscle pain: carrageenan model and acidic saline model. Curr Protoc Pharmacol. 2004; Chapter 5: Unit 5.35.
Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience. 2016; 338: 114-129.
Suárez-Roca H, Quintero L, Arcaya JL, Maixner W, Rao SG. Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran. Physiol Behav. 2006; 88 (1-2): 82-87.
Nagakura Y, Oe T, Aoki T, Matsuoka N. Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. Pain. 2009; 146: 26-33.
Munro G. Comment on Biogenic amine depletion as a putative animal model of fibromyalgia. Pain. 2010; 148 (1): 172-173.
Vinegar R, Truax JF, Selph JL, Johnston PR. New analgesic assay utilizing trypsin-induced hyperalgesia in the hind limb of the rat. J Pharmacol Methods. 1990; 23: 51-61.
Green AF, Young PA, Godfrey EI. A comparison of heat and pressure analgesimetric methods in rats. Br J Pharmacol. 1951; 6: 572-585.
Schmidt-Wilcke T, Clauw DJ. Fibromyalgia: from pathophysiology to therapy. Nat Rev Rheumatol. 2011; 7 (9): 518-527.
Cabo-Meseguer A, Cerda-Olmedo G, Trillo-Mata JL. Fibromyalgia: prevalence, epidemiologic profiles and economic costs. Medicina Clínica (Barc). 2017; 149: 441-448.
Hauser W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C et al. Fibromyalgia. Nat Rev Dis Primers. 2015; 1: 15022.
Maletic V, Raison CL. Neurobiology of depression, fibromyalgia and neuropathic pain. Front Biosci (Landmark Ed). 2009; 14 (14): 5291-338.
Liu YT, Shao YW, Yen CT, Shaw FZ. Acid-induced hyperalgesia and anxio-depressive comorbidity in rats. Physiol Behav. 2014; 131: 105-110.
Green PG, Alvarez P, Gear RW, Mendoza D, Levine JD. Further validation of a model of fibromyalgia syndrome in the rat. J Pain. 2011; 12 (7): 811-818.
Nasu T, Kubo A, Queme LF, Mizumura K. A single administration of Neurotropin reduced the elongated immobility time in the forced swimming test of rats exposed to repeated cold stress. Behav Pharmacol. 2019; 30 (7): 547-554.
Khasar SG, Burkham J, Dina OA, Brown AS, Bogen O, Alessandri-Haber N et al. Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain. J Neurosci. 2008; 28 (22): 5721-5730.
Nazeri M, Zarei MR, Pourzare AR, Ghahreh-Chahi HR, Abareghi F, Shabani M. Evidence of altered trigeminal nociception in an animal model of fibromyalgia. Pain Med. 2018; 19: 328-335.
Goebel A, Krock E, Gentry C, Israel MR, Jurczak A, Urbina CM et al. Passive transfer of fibromyalgia symptoms from patients to mice. J Clin Invest. 2021; 131 (13): e144201.
Furuta A, Suzuki Y, Honda M, Koike Y, Naruoka T, Asano K et al. Time-dependent changes in bladder function and plantar sensitivity in a rat model of fibromyalgia syndrome induced by hydrochloric acid injection into the gluteus. BJU Int. 2012; 109 (2):
-310.
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