Genetic polymorphisms of the ROMO1 intronic regions are not associated with the development of knee osteoarthritis
Keywords:
Osteoarthritis, reactive oxygen species modulator 1, ROMO1 gene, single nucleotide polymorphisms, oxidative stressAbstract
Osteoarthritis (OA) is a degenerative disorder that is characterized by articular cartilage break-
down, osteophytes formation, and subchondral bone sclerosis; its development and progression
are mediated by proinflammatory mediators, as well as by reactive oxidative species (ROS).
Recently there has been identified a mitochondrial protein called Romo1 that modulates ROS
in different states of oxidative stress, and which is encoded by the gene ROMO1. This gene
has single nucleotide polymorphisms (SNPs) that could affect the translation of the different
isoforms of its associated protein, and it is unknown whether these could have implications in the modulation of ROS in patients with OA. The aim of this work was evaluate two polymor- phisms of ROMO1 gene in samples of patients with knee OA. We found that the analyzed polymorphisms are not associated with the presence of OA, therefore are not useful markers for genetic studies of OA in Mexican population.
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Copyright (c) 2016 Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra
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