The role of the immune system in the development of sepsis after burns
Keywords:
Burns, sepsis, infections, immune system, innate immunity, adaptive immunityAbstract
Burns are a destructive form of trauma that remain a major cause of morbidity and mortality worldwide; despite the improvements in medical care, burns often leave lifelong physical and emotional sequelae. Likewise, infectious complications, including sepsis and septic shock are common in patients with moderate to severe burn injuries. In this regard, sepsis is a life-threatening disturbance produced by a dysregulated reaction to infections,
which can cause serious complications and lead to death. Therefore, the study of pathophysiological mechanisms related to development of sepsis is pivotal. In this article, we perform a comprehensive description of immune processes associated with burn injury, particularly the mechanisms involved in the development of sepsis after burns. In addition, we provide relevant information about immune mediators potentially useful as biomarkers of sepsis.
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Copyright (c) 2018 Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra under a Creative Commons Attribution 4.0 International (CC BY 4.0) license which allows to reproduce and modify the content if appropiate recognition to the original source is given.
