Volumetric bone mineral density measured by quantitative computed tomography: reference values for the mexican pediatric population
DOI:
https://doi.org/10.35366/103938Keywords:
Peak bone mass, quantitative computed tomography, volumetric bone mineral density, Pediatric vBMD, DXAAbstract
Introduction: Nowadays, childhood diseases as Duchenne muscular dystrophy (DMD) have
raised interest in pediatric bone densitometry, since long-term steroid therapy is a serious risk
factor for osteoporosis. Even though dual energy X-ray absorptiometry (DXA) is the most used
technique to measure bone mineral density (BMD), quantitative computed tomography (QCT)
is the most exact way to assess bone health. But the reference values are available for adult
populations, and only for a few pediatric populations. Objective: The aim of this study is to
measure volumetric BMD (vBMD) values using QCT to determine the reference values of healthy
Mexican pediatric population. Material and methods: This is an observational transversal
study to measure vBMD from three images of healthy trabecular lumbar spine using QCT.
Results: vBMD data has a sigmoid behavior in both genders, with a delayed start for males;
the difference in values during puberty have a moderate significant correlation (-0.546, p=0.004). vBMD values for both genders are 40% lower than the reported for Caucasian pediatric
population. Conclusion: These results encourage us to continue this study to increase the
confidence of the obtained vBMD reference values for Mexican pediatric population. This will
have a high impact in diagnosis accuracy, particularly in chronically ill children, with DMD and
other musculoskeletal diseases.
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