Muscle and cancer: a bidirectional relationship. Pathophysiology and consequences

Authors

  • Lluvia Itzel León-Reyes Servicio de Neuropediatría, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE). Programa de Maestría en Ciencias de la Salud, Escuela Superior de Medicina, Instituto Politécnico Nacional. Ciudad de México, México.
  • Patricia Canto Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM). Subdirección de Investigación Clínica, Dirección de Investigación, Instituto Nacional de Ciencias Médicas y Nutrición «Salvador Zubirán». Ciudad de México, México.
  • Ramón M Coral-Vázquez Sección de Estudios de Postgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional. Subdirección de Enseñanza e Investigación, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE). Ciudad de México, México.

DOI:

https://doi.org/10.35366/112699

Keywords:

sarcopenia, cancer, mortality, survival, chemotherapy, radiotherapy

Abstract

The muscle has very important interrelationships with other organs such as the heart, liver, brain

and adipose tissue. Its wear, known as sarcopenia, has been associated with different types of

cancer during treatment, which causes an increase in toxicity derived from both, chemotherapy and

radiotherapy. This causes treatment delays and unwanted dose adjustments that negatively impact

the survival of cancer patients. There is evidence that suggests that sarcopenia persists even in

the survival stage, conditioning a negative impact on the quality of life of patients and on their work

productivity. Different physiopathological mechanisms at the cellular and molecular level involved in

sarcopenia in cancer are known, which increasingly show a bidirectional relationship, both positive

and negative, between cancer and muscle.

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2024-06-06

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1.
León-Reyes LI, Canto P, Coral-Vázquez RM. Muscle and cancer: a bidirectional relationship. Pathophysiology and consequences. InDiscap [Internet]. 2024 Jun. 6 [cited 2024 Nov. 22];9(3):136-4. Available from: http://dsm.inr.gob.mx/indiscap/index.php/INDISCAP/article/view/51

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Vol. 9 No. 3 (2023)

Section

Evidence synthesis and meta-research

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