Myogenic compromise of satellites cells in muscular dystrophies
DOI:
https://doi.org/10.35366/113830Keywords:
satellites cells, muscle regeneration, muscular dystrophiesAbstract
Satellites cells make up a heterogeneous group of cells that includes stem cells and skeletal muscle progenitor cells. These specialized muscle cells play a key role in muscle regeneration. During a process of severe damage to the muscle fiber, the muscle regeneration machinery is launched, involving several signaling pathways that lead to the activation of satellites cells. The above directs the muscle to carry out an orderly repair mechanism. However, it has been proposed that the reduction or loss of muscle repair capacity after injury, with a concomitant decrease in myogenic commitment of satellites cells, could be the cause of the damage observed in various forms of muscular dystrophy. The myogenic commitment of satellites cells can be affected by different mechanisms, such as the state of chronic inflammation, the deregulation of fibro-adipogenic progenitors or the senescence process. All of this results in a decrease in muscle regenerative capacity and further muscle degeneration. The purpose of this review is to describe some of the most relevant mechanisms that alter the myogenic commitment of satellites cells and how these influence the decrease in muscle repair in muscles affected by muscular dystrophy.
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Copyright (c) 2024 Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra
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© Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra under a Creative Commons Attribution 4.0 International (CC BY 4.0) license which allows to reproduce and modify the content if appropiate recognition to the original source is given.
