Therapeutic applications of non-invasive brain stimulation in neurorehabilitation

Authors

  • María Inés Hernández-Gutiérrez Médico Residente de Medicina de Rehabilitación. Instituto Nacional de Rehabilitación.
  • Paul Carrillo-Mora Departamento de Neurociencias/Subdivisión de Neuro-biología. Instituto Nacional de Rehabilitación «Dr. Luis Guillermo Ibarra Ibarra».

Keywords:

Transcranial magnetic stimulation, transcranial direct current stimulation, neurorehabilitation, stroke, traumatic brain injury

Abstract

Techniques of non-invasive brain stimulation (NIBS) are clinical tools that are currently in

extensive research and development as novel therapeutic options for patients with acquired

brain damage. The two most widely used techniques are repetitive transcranial magnetic

stimulation (rTMS) and transcranial direct current stimulation (TDCS), which are based on

the external electric or magnetic current application on the skull to modulate (stimulate or

inhibit) the neuronal and brain activity. The NIBS in conjunction with neurorehabilitation

conventional therapies have the potential ability to enhance motor, cognitive, sensory

and functional recovery in patients with several neurological disorders with an additional

excellent safety and tolerability profile. There is now evidence of its positive effects in many diseases such as stroke, Parkinson’s disease (PD), spinal cord injury (SCI), traumatic brain injury (TBI), cerebral palsy (CP), autism spectrum disorders (ASD), among others. The aim of this paper is to bring updated review on the basic principles of NIBS most used, as well as on the clinical applications that have shown positive effects in the area of neurorehabilitation.

References

Liew SL, Santarnecchi E, Buch ER, Cohen LG. Non- invasive brain stimulation in neurorehabilitation: local and distant effects for motor recovery. Front Hum Neurosci. 2014; 8: 378.

Machado S, Bittencourt J, Minc D, Portella CE,

Velasques B, Cunha M et al. Therapeutic applications

of repetitive transcranial magnetic stimulation in clinical

neurorehabilitation. Funct Neurol. 2008; 23 (3): 113-122.

Parkin BL, Ekhtiari H, Walsh VF. Non-invasive human brain stimulation in cognitive neuroscience: a primer.

Neuron. 2015; 87 (5): 932-945.

Klomjai W, Katz R, Lackmy-Vallée A. Basic principles of

transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS). Ann Phys Rehabil Med. 2015; 58 (4): 208-213.

Lefaucheur JP, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014; 125 (11): 2150-2206.

Woods AJ, Antal A, Bikson M, Boggio PS, Brunoni AR, Celnik P et al. A technical guide to tDCS, and related non-invasive brain stimulation tools. Clin Neurophysiol. 2016; 127 (2): 1031-1048.

Roche N, Geiger M, Bussel B. Mechanisms underlying transcranial direct current stimulation in rehabilitation. Ann Phys Rehabil Med. 2015; 58 (4): 214-219.

Klomjai W, Lackmy-Vallée A, Roche N, Pradat-Diehl P, Marchand-Pauvert V, Katz R. Repetitive transcranial magnetic stimulation and transcranial direct current stimulation in motor rehabilitation after stroke: an update. Ann Phys Rehabil Med. 2015; 58 (4): 220-224.

Hamilton RH, Chrysikou EG, Coslett B. Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain Lang. 2011; 118 (1-2): 40-50.

Grefkes C, Ward NS. Cortical reorganization after stroke: how much and how functional? Neuroscientist. 2014; 20 (1): 56-70.

Adeyemo BO, Simis M, Macea DD, Fregni F. Systematic review of parameters of stimulation, clinical trial design characteristics, and motor outcomes in non- invasive brain stimulation in stroke. Front Psychiatry. 2012; 3: 88.

LeQ,QuY,TaoY,ZhuS.Effectsofrepetitivetranscranial magnetic stimulation on hand function recovery and excitability of the motor cortex after stroke: a meta- analysis. Am J Phys Med Rehabil. 2014; 93 (5): 422-430.

Tedesco TL, Burridge JH, Hughes AM, Pickering RM, Desikan M, Rothwell JC et al. Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta- analysis. Clin Neurophysiol. 2016; 127 (1): 946-955.

Kang N, Summers JJ, Cauraugh JH. Transcranial direct current stimulation facilitates motor learning post- stroke: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016; 87 (4): 345-355.

Tsai PY, Wang CP, Ko JS, Chung YM, Chang YW, Wang JX. The persistent and broadly modulating effect of inhibitory rTMS in nonfluent aphasic patients: a sham- controlled, double-blind study. Neurorehabil Neural Repair. 2014; 28 (8): 779-787.

Elsner B, Kugler J, Pohl M, Mehrholz J. Transcranial

direct current stimulation (tDCS) for improving aphasia

in patients after stroke. Cochrane Database Syst Rev.

; (6): CD009760.

Khedr EM, Abo-Elfetoh N, Rothwell JC. Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation. Acta Neurol Scand. 2009; 119 (3): 155-161.

Park JW, Oh JC, Lee JW, Yeo JS, Ryu KH. The effect of 5Hz high-frequency rTMS over contralesional pharyngeal motor cortex in post-stroke oropharyngeal dysphagia: a

randomized controlled study. Neurogastroenterol Motil.

; 25 (4): 324-e250.

Dhaliwal SK, Meek BP, Modirrousta MM. Non-invasive

brain stimulation for the treatment of symptoms following

traumatic brain injury. Front Psychiatry. 2015; 6: 119.

Koski L, Kolivakis T, Yu C, Chen JK, Delaney S, Ptito A. Noninvasive brain stimulation for persistent postconcussion symptoms in mild traumatic brain injury.

J Neurotrauma. 2015; 32 (1): 38-44.

Thibaut A, Bruno MA, Ledoux D, Demertzi A, Laureys S.

tDCS in patients with disorders of consciousness: sham- controlled randomized double-blind study. Neurology. 2014; 82 (13): 1112-1118.

Middleton A, Fritz SL, Liuzzo DM, Newman-Norlund R, Herter TM. Using clinical and robotic assessment tools to examine the feasibility of pairing tDCS with upper extremity physical therapy in patients with stroke and TBI: a consideration-of-concept pilot study. NeuroRehabilitation. 2014; 35 (4): 741-754.

ChouYH,HickeyPT,SundmanM,SongAW,ChenNK. Effects of repetitive transcranial magnetic stimulation on motor symptoms in Parkinson disease: a systematic review and meta-analysis. JAMA Neurol. 2015; 72 (4): 432-440.

Wagle Shukla A, Shuster JJ, Chung JW, Vaillancourt DE, Patten C, Ostrem J et al. Repetitive transcranial magnetic stimulation (rTMS) therapy in parkinson disease: a meta-analysis. PM R. 2016; 8 (4): 356-366.

PalE,NagyF,AschermannZ,BalazsE,KovacsN.The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson’s disease: a randomized, double-blind, placebo-controlled study. Mov Disord. 2010; 25 (14): 2311-2317.

Fregni F, Santos CM, Myczkowski ML, Rigolino R, Gallucci-Neto J, Barbosa ER et al. Repetitive transcranial magnetic stimulation is as effective as fluoxetine in the treatment of depression in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2004; 75: 1171-1174.

LefaucheurJP.Corticalneurostimulationforneuropathic pain : state of the art and perspectives. Pain. 2016;157 Suppl 1: S81-89.

Khedr EM, Kotb H, Kamel NF, Ahmed MA, Sadek R, Rothwell JC. Longlasting antalgic effects of daily sessions of repetitive transcranial magnetic stimulation in central and peripheral neuropathic pain. J Neurol Neurosurg Psychiatry. 2005; 76: 833-938.

Hosomi K, Shimokawa T, Ikoma K, Nakamura Y, Sugiyama K. Daily repetitive transcranial magnetic

stimulation of primary motor cortex for neuropathic pain: a randomized, multicenter, double-blind, crossover, sham-controlled trial. Pain. 2013; 154 (7): 1065-1072.

Tazoe T, Perez MA. Effects of repetitive transcranial magnetic stimulation on recovery of function after spinal cord injury. Arch Phys Med Rehabil. 2015; 96: S145-S155.

Nardone R, Höller Y, Thomschewski A, Brigo F, Orioli A, Höller P et al. rTMS modulates reciprocal inhibition in patients with traumatic spinal cord injury. Spinal Cord. 2014; 52 (11): 831-835.

Benito J, Kumru H, Murllo N, Costa U, Medina J, Tormos JM et al. Motor and gait improvement in patients with incomplete spinal cord injury induced by highfrequence repetitive transcranial magnetic stimulation. Top Spinal Cord Inj Rehabil. 2012; 18: 106-112.

Rajapakse T, Kirton A. Non-invasive brain stimulation in children: applications and future directions. Transl Neurosci. 2013; 4 (2). doi: 10.2478/s13380-013-0116-3.

Frye RE, Rotenberg A, Ousley M, Pascual-Leone A. Transcranial magnetic stimulation in child neurology: current and future directions. J Child Neurol. 2008; 23: 79-96.

Valle AC, Dionisio K, Pitskel NB, Pascual-Leone A, Orsati F, Ferreira MJ. Low and high frequency repetitive transcranial magnetic stimulation for the treatment of spasticity. Dev Med Child Neurol. 2007; 49: 534-538.

Kirton A, Chen R, Friefeld S, Gunraj C, Pontigon AM, Deveber G. Contralesional repetitive transcranial magnetic stimulation for chronic hemiparesis in subcortical paediatric stroke: a randomised trial. Lancet Neurol. 2008; 7: 507-513.

Grecco LA, de Almeida CD, Mendonça ME, Cimolin V, Galli M, Fregni F et al. Transcranial direct current stimulation during treadmill training in children with cerebral palsy: A randomized controlled double-blind clinical trial. Res Dev Disabil. 2014; 35: 2840-2848.

Baruth JM, Casanova MF, El-Baz A, Horrell T, Mathai G, Sears L et al. Low-frequency repetitive transcranial magnetic stimulation (rTMS) modulates evoked-gamma frequency oscillations in autism spectrum disorder (ASD). J Neurother. 2010; 14: 179-194.

Schneider HD, Hopp JP. The use of the bilingual aphasia test for assessment and transcranial direct current stimulation to modulate language acquisition in minimally verbal children with autism. Clin Linguist Phon. 2011; 25: 640-654.

KhedrEM,AhmedMA,FathyN,RothwellJC.Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke. Neurology. 2005; 65 (3): 466-468.

Khedr EM, Etraby AE, Hemeda M, Nasef AM, Razek AA. Long-term effect of repetitive transcranial magnetic stimulation on motor function recovery after acute ischemic stroke. Acta Neurol Scand. 2010; 121: 30-37.

Chang WH, Kim YH, Bang OY, Kim ST, Park YH, Lee PK. Long-term effects of rTMS on motor recovery in

patients after subacute stroke. J Rehabil Med. 2010; 42: 758-764.

EmaraTH,MoustafaRR,ElnahasNM,ElganzouryAM, Abdo TA, Mohamed SA et al. Repetitive transcranial magnetic stimulation at 1 Hz and 5 Hz produces sustained improvement in motor function and disability after ischaemic stroke. Eur J Neurol. 2010; 17: 1203-1209.

Published

2024-08-19

How to Cite

1.
Hernández-Gutiérrez MI, Carrillo-Mora P. Therapeutic applications of non-invasive brain stimulation in neurorehabilitation. InDiscap [Internet]. 2024 Aug. 19 [cited 2024 Nov. 22];6(1):25-33. Available from: http://dsm.inr.gob.mx/indiscap/index.php/INDISCAP/article/view/340

Issue

Section

Evidence synthesis and meta-research

Most read articles by the same author(s)

Similar Articles

1 2 3 4 > >> 

You may also start an advanced similarity search for this article.